Ameet Mallik taps fellow Novartis alum to lead business development at ADC Therapeutics – Endpoints News


Just one month into his CEO tenure at ADC Therapeutics, Ameet Mallik is bringing in new people to assemble his top team.
David Gilman, a seasoned biopharma consultant who held a brief stint scouting deals for Novartis’ oncology group, is joining the Swiss biotech as chief business and strategy officer.
A veteran of Novartis himself, Mallik jumped to ADC last month after his first CEO experience at Rafael Holdings imploded, replacing Chris Martin, the long-time chief who’d been involved with the company since its formation in 2011 and oversaw a slate of financings, deals, an IPO and an FDA approval.
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The numbers are somewhat in and biotech diversity looks relatively similar to what it has been for years.
A 2021 sampling paints a very limited picture of the industry, with BIO’s third annual diversity report including only 99 respondent companies. Most questions were not or could not be answered by every single organization, meaning many went unanswered, such as insight on board-level demographics.
Ali Raza Khaki is a bladder cancer doctor at Stanford. He’s seen five immune checkpoint inhibitors approved as a second line of treatment, but he really only uses one for that indication — pembrolizumab, marketed as Keytruda, since it’s the only one with randomized controlled trial data.
Two of the other inhibitors, AstraZeneca’s Imfinzi and Roche’s Tecentriq, have since had their accelerated approvals for bladder cancer pulled by the FDA (or rather, the Big Pharmas ‘voluntarily withdrew’ them).
Though the FDA earlier this month told Amylyx Pharmaceuticals the agency would need a little bit longer to review its ALS drug’s application, one country is forging ahead with a green light.
Canada approved Amylyx’s ALS drug AMX0035 early Monday morning, giving the biotech its first green light and ALS patients in the country only the third therapy available to treat the disease. The decision also marks a win for Amylyx, a one-drug biotech that went all-in on ALS — one of the most challenging diseases for drug R&D — and whose fortunes appeared murky after the FDA raised concerns over its data at an advisory committee meeting in March.
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From first-timers to long-timers, marketing creatives and executives can’t wait to get back to the Cannes Lions Festival of Creativity for advertising that begins next week in the south of France. For pharma marketers though, it’s a return to Cannes Lion health with a small “h” this time.
That’s because while Cannes Lions 2022 marks the welcome return to in-person programming and award shows, it’s a new dynamic for health and pharma marketers with no separate Cannes Lions Health conference for the first time.
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Pfizer debuted its first TV commercial for Cibinqo, its next-gen oral JAK inhibitor to treat eczema, with a splashy special effects spot about the “new innovation from Pfizer.” Cibinqo, or abrocitinib, was approved in January for moderate-to-severe atopic dermatitis that’s not responsive to other systemic drugs.
The new “innovation” TV ad reflects Pfizer’s confidence in the steroid-free drug it expects to take in peak sales of $3 billion. Still, Cibinqo’s approval came with serious safety warnings which are also reflected in the ads.
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Pfizer, Concert Pharmaceuticals and Eli Lilly were all gunning to be the first company to bring an alopecia areata drug to market. But Lilly crossed the finish line first Monday.
The Indianapolis-based pharma announced that FDA had approved JAK inhibitor baricitinib, aka Olumiant, for patients with severe forms of the autoimmune disorder alopecia areata (AA), which results in hair loss. The drug, which was approved as a once-daily pill in three dose levels of 1 mg, 2 mg and 4 mg for the indication, had been originally discovered by Incyte before Lilly in-licensed it back in 2009.
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Roughly 24 hours after Canadian regulators gave Amylyx Pharmaceuticals the thumbs-up for its new ALS drug, ICER is out with a new analysis trying to determine whether the drug would be cost effective. And the short answer is no — for now.
Though Amylyx has not disclosed how much it intends to charge for the drug, branded as Albrioza, ICER pegged its estimated cost to an older ALS medicine, edaravone. If Albrioza costs $169,000 per year, as edaravone currently does, the drug would not be cost effective to the US healthcare system, and far from it, ICER says.
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For those tracking the progress of genome editing, the Broad Institute of Harvard and MIT’s David Liu likely needs no introduction (Google him for a refresher), and 2022 might be the year that the editing techniques he and his lab created start to make real strides in the clinic.
Liu’s lab has pioneered two new elegant and precise ways to cut DNA and replace bases with precision, but without making any of the DNA double-stranded breaks that can sometimes lead to off-target effects.
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The latest rival to Alnylam’s drug for hereditary transthyretin-mediated (hATTR) amyloidosis is here — and it comes from Alnylam itself.
Four years after the groundbreaking approval of Onpattro, the world’s first RNAi therapy, the FDA has approved vutrisiran, Alnylam’s next-generation treatment, for polyneuropathy of hATTR in adults. It will be marketed as Amvuttra.
Whereas Onpattro is administered as an intravenous injection every three weeks, Amvuttra is given subcutaneously once every three months.
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