Macular degeneration vs. retinitis pigmentosa – Medical News Today


Macular degeneration (MD) and retinitis pigmentosa (RP) are eye diseases that affect the retina, which is the light-sensitive layer of tissue at the back of the eye. Alongside a functioning center called the macula, the retina contains photoreceptors, the optic nerve, and blood vessels.
When light hits the retina, the photoreceptors convert the light into electrical signals. The optic nerve sends these signals to the brain, enabling a person to see.
A damaged retina due to MD or RP causes varying degrees of vision loss. Whereas MD occurs due to aging, RP is an inherited disease that typically develops in childhood or young adulthood.
This article provides an overview of MD and RP, including the links and differences between the two diseases. It also discusses the symptoms and causes of each disease and provides a list of other eye conditions that may cause symptoms similar to those of MD and RP.
Below, we look at MD and RP in more detail.
MD is an eye disease that involves damage to the macula, which is the light-sensitive tissue that forms part of the retina. The condition causes changes to a person’s central vision, which is what a person sees while looking straight ahead. Central vision is helpful for the following:
MD does not affect a person’s peripheral vision, which is what a person sees on the periphery of their central vision, outside the point of fixation.
According to the National Eye Institute (NEI), MD affects 11 million people in the United States. It is also the leading cause of vision loss in older adults, primarily affecting people aged 55 years and older.
There are two types of MD: dry and wet. Dry MD occurs when the macula becomes thinner with age. Wet MD occurs when abnormal blood vessels grow underneath the macula and leak blood and fluid that results in scarring and vision loss.
According to the American Academy of Ophthalmology (AAO), about 80% of people who have MD have the dry form. However, it is possible for people to develop both dry and wet MD.
Learn more about age-related macular degeneration.
RP is an umbrella term for rare eye disorders that cause the breakdown and loss of cells in the retina.
The National Organization for Rare Disorders states that RP is a rare genetic disorder that affects somewhere between 82,500 and 110,000 people in the U.S. The symptoms typically start between the ages of 10 and 40 years and gradually worsen over time.
According to the NEI, the most common early symptom of RP is night blindness.
Learn more about retinitis pigmentosa.
According to a 2018 study, RP and MD may both involve issues with the immune system and inflammation. The study involved participants with various eye conditions, including MD and RP. The researchers found that both diseases were associated with increased levels of inflammatory markers within the participants’ eye fluids.
Researchers have also found that mutations in the peripherin-2 (PRPH2) gene may be associated with the development of both MD and RP.
Healthy peripherin-2 protein is necessary for the proper functioning of photoreceptors called rods and cones, which are responsible for sight. Rods work at low levels of light, while cones allow a person to see color. Rod damage causes RP, while cone degeneration causes MD.
MD and RP both cause loss of vision. The table below shows the differences between the two disorders:
MD and RP both affect the vision, but they produce different symptoms.
MD is a progressive disease, meaning that the symptoms usually worsen over time.
The symptoms of MD depend on the stage of the disease. There are three disease stages:
The symptoms of RP vary from person to person, but they may include:
MD and RP have different causes and risk factors.
MD develops due to a combination of genetic and environmental factors.
The risk of MD increases with aging. According to the AAO, the following factors can also increase the risk:
A person can reduce their risk of developing MD by quitting smoking or never starting.
RP occurs due to a genetic disorder. The National Institutes of Health (NIH) note that genetic changes to any one of more than 50 genes may cause RP.
In some cases, RP develops due to another genetic condition, such as Usher syndrome.
Possible risks and complications of MD and RP include:
Other eye conditions that may cause symptoms similar to those of MD and RP include:
A person with MD or RP will develop varying levels of vision loss.
Treatments do not cure MD and RP, but they may help slow the progression of these diseases. In addition, therapies such as vision rehabilitation can help a person deal with vision loss from MD and RP.
More treatment options are available for MD than for RP. Often, people with RP can seek help from eye doctors specializing in low vision.
The American Foundation for the Blind provides resources to help people manage new vision loss.
Macular degeneration and retinitis pigmentosa are eye disorders that can cause vision loss. Whereas MD is an age-related condition, RP is an inherited condition that typically develops in childhood or young adulthood.
Several other eye conditions can cause symptoms similar to those of MD and RP. A person who experiences any concerning eye symptoms should consult an eye doctor for a diagnosis.
Although there is no cure for either MD or RP, early detection and treatment can help slow disease progression and prevent possible complications. In addition, therapies such as vision rehabilitation can help a person deal with vision loss. Anyone needing further advice and guidance should talk with an eye doctor.
Last medically reviewed on April 27, 2022





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