Ophthalmic manifestations of monkeypox virus | Eye – Nature.com

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Monkeypox virus (MPXV), a double-stranded DNA virus belonging to the Orthopox genus of the Poxviridae family, was first reported as a zoonotic infection transmitted from animals to humans in 1958, with the first human case being reported in 1970. The first human-to-human transmission outbreak was reported in 1996–1997 in the Democratic Republic of Congo through respiratory droplets and direct contact with infected individuals [1]. Then, sexual transmission in men having sex with other men (MSM) became evident [2]. Notably, MPXV re-emerged in May 2022 in multiple countries with no evident epidemiological link between reported cases. As of July 3rd, 2022, the total number of confirmed cases reached 6178 in 56 countries, being highest in Spain (N = 1196), England (N = 1185), Germany (N = 1054), France (N = 498), and the United States (N = 459) (Fig. 1).
Confirmed Monkeypox cases worldwide as of July 3, 2022.
The presenting symptoms of MPXV are quite similar to those of smallpox with an incubation period ranging from 5 to 21 days [3]. However, available evidence highlights the presence of several yet frequent ophthalmic manifestations that are associated with this virus. Given the current burden of the disease, and the fact that it was declared a pandemic by the World Health Network (WHN) on June 22, 2022 [4], such symptoms should be recognized by healthcare workers, particularly ophthalmologists.
The clinical picture of the MPXV is very similar to that of the ordinary and modified forms of smallpox [5, 6]. Lymphadenopathy, occurring in the early stage of the illness, is a distinctive hallmark differentiating human monkeypox from smallpox and chickenpox [5, 6]. MXPV has been reported to have several ophthalmic manifestations which are common like other non-specific symptoms (i.e., fatigue, headache, muscle ache) [5, 6]. For instance, the characteristic lesions of MPXV usually appear as first macular, then papular, then vesicular and pustular which often involve peri-orbital and orbital skin, resembling Varicella-Zoster rash, which affect 25% of cases [7]. A full list of ophthalmological manifestations of MPXV is provided in Table 1.
Conjunctivitis and edema of the eyelids were common (approximately over 20% of affected patients) and resulted in substantial but temporary distress to the affected patients [5, 7,8,9]. Interestingly, Jezek Z et al. [10] showed that conjunctivitis was more common among patients affected by animal MPXV (20.3%) compared to those affected by human MPXV (16.4%). Furthermore, focal lesions on the conjunctiva and along the margins of the eyelids were seen with a greater incidence among unvaccinated patients with confirmed MPXV (nearly 25%, 68/294) [5, 11]. Hughes et al. [9] reported that patients, where “conjunctivitis” was observed, had a higher frequency of other symptoms, such as nausea, chills/sweating, oral ulcers, sore throat, general malaise, lymphadenopathy, and photophobia compared to those with no reported “conjunctivitis”. In addition, conjunctivitis is likely predictive of the illness course. For example, 47% of patients with conjunctivitis reported being “bed-ridden”, compared to 16% of patients where “conjunctivitis” was not reported [9].
Corneal involvement may range from mild to severe involvement. Photophobia, alone, was reported in approximately 22% of affected patients [7]. In addition, severe corneal infections that can result in severe keratitis forms (seen in 7.5% of patients in one study), corneal scarring (seen in 4% of unvaccinated, and 1% of previously smallpox-vaccinated case patients), and permanent vision loss were also reported [6,7,8, 10]. Based on the study of Jezek et al. [10], unilateral or bilateral blindness, and weak vision were observed in 10% of primary (who presumably were infected from an animal source) and 5% of secondary cases (in whom the rash appeared between 7 and 21 days after exposure to another human case which may have occurred due to person-to-person transmission). Of note, Trifluridine has been used to treat Orthopoxvirus-associated corneal lesions. However, there is no available evidence of its efficacy in MPXV cases specifically [9]. We should not forget to mention that MPXV causes lymphadenopathy, which may involve pre-auricular lymph nodes as seen in viral conjunctivitis [5,6,7,8, 12]. Frontal headache involving the orbits was also reported [5, 6, 8, 12]. Furthermore, one study showed that blepharitis was observed in 30% of unvaccinated, and in 7% of previously smallpox-vaccinated patients [13].
Monkeypox is usually a self-limited disease with symptoms lasting from two to four weeks [8]. The potential benefits of relatively simple therapies for ocular complications, such as enhanced lubrication or topical antibiotics, could be considered [11]. Of note, severe sequelae and complications of monkeypox occur more commonly among unvaccinated populations (74%) compared to vaccinated patients (39.5%) [5, 6, 8, 14]. Therefore, we should highlight the importance of the vaccine by increasing public awareness. However, an accidental infection may occur secondary to vaccine strains themselves [15]. In the 5 years between 1963 and 1968, ocular vaccinia was observed in 348 persons: 259 vaccinees and 66 contacts. Of these, 22 had evidence of corneal involvement, and 11 had permanent defects [14]. In addition, ophthalmologists should be aware of any new ocular complaints following confirmed MPXV. Improving the availability of ophthalmologic resources in areas endemic to the MPXV may reduce risks for significant visual sequelae among affected patients.
Since the majority of MPXV-associated ophthalmic manifestation surpass the rare event assumption (<5%), and given the continuous and rapid increase in the number of cases, we highly recommend that ophthalmologists incorporate MPXV as a part of their differential diagnosis when they come across similar cases presenting with ophthalmic manifestations like conjunctivitis, blepharitis, keratitis, or corneal lesions. And since these manifestations are more likely observed in non-vaccinated individuals, we, therefore, encourage healthcare authorities to redistribute the smallpox vaccine for high-risk groups.
Bragazzi NL, Khamisy-Farah R, Tsigalou C, Mahroum N, Converti M. Attaching a stigma to the LGBTQI+ community should be avoided during the monkeypox epidemic. J Med Virol. 2022. Online ahead of print.
Bragazzi NL, Kong JD, Mahroum N, Tsigalou C, Khamisy-Farah R, Converti M, et al. Epidemiological trends and clinical features of the ongoing monkeypox epidemic: a preliminary pooled data analysis and literature review. J Med Virol. 2022. Online ahead of print.
Velavan TP, Meyer CG Monkeypox 2022 outbreak: an update. Trop Med Int Health. 2022;27:604–5.
Swiss Institute of Bioinformatics (SIB). Orthopoxvirus. Viral Zone. https://viralzone.expasy.org/149?outline=all_by_species. Accessed 25 May 2022.
Ježek Z, Szczeniowski M, Paluku K, Mutombo M. Human monkeypox: clinical features of 282 patients. J Infect Dis. 1987;156:293–8.
Article  Google Scholar 
McCollum AM, Damon IK. Human monkeypox. Clin Infect Dis. 2014;58:260–7.
Article  Google Scholar 
Ogoina D, Iroezindu M, James HI, Oladokun R, Yinka-Ogunleye A, Wakama P, et al. Clinical course and outcome of human monkeypox in Nigeria. Clin Infect Dis. 2020;71:e210–e4.
Article  Google Scholar 
Farahat RA, Abdelaal A, Shah J, Ghozy S, Sah R, Bonilla‑Aldana DK, et al. Monkeypox outbreaks during COVID-19 pandemic: are we looking at an independent phenomenon or an overlapping pandemic? Ann Clin Microbiol Antimicrob. 2022;21:26.
Hughes C, McCollum A, Pukuta E, Karhemere S, Nguete B, Lushima RS, et al. Ocular complications associated with acute monkeypox virus infection, DRC. Int J Infect Dis. 2014;21:276–7.
Article  Google Scholar 
Ježek Z, Grab B, Szczeniowski M, Paluku K, Mutombo M. Clinico-epidemiological features of monkeypox patients with an animal or human source of infection. Bull World Health Organ. 1988;66:459.
PubMed  PubMed Central  Google Scholar 
Reynolds MG, McCollum AM, Nguete B, Shongo Lushima R, Petersen BW. Improving the care and treatment of monkeypox patients in low-resource settings: applying evidence from contemporary biomedical and smallpox biodefense research. Viruses. 2017;9:380.
Article  Google Scholar 
Huhn GD, Bauer AM, Yorita K, Graham MB, Sejvar J, Likos A, et al. Clinical characteristics of human monkeypox, and risk factors for severe disease. Clin Infect Dis. 2005;41:1742–51.
Article  Google Scholar 
Damon IK. Status of human monkeypox: clinical disease, epidemiology and research. Vaccine. 2011;29:D54–D9.
Article  Google Scholar 
Ruben FL, Lane JM. Ocular vaccinia: an epidemiologic analysis of 348 cases. Arch Ophthalmol. 1970;84:45–8.
CAS  Article  Google Scholar 
Petersen BW, Karem KL, Damon IK. Orthopoxviruses: Variola, Vaccinia, Cowpox, and Monkeypox. In: Viral infections of humans. Boston, MA: Springer; 2014. p. 501–17.
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Tanta Research Team (TRT), Tanta, El-Gharbia, Egypt
Abdelaziz Abdelaal, Hashem Abu Serhan & Mariam Abdelmageed Mahmoud
Research Scholar, Harvard Medical School, Boston, MA, 02155, USA
Abdelaziz Abdelaal & Ranjit Sah
Boston University, School of Medicine, Boston, MA, USA
Abdelaziz Abdelaal
Faculty of Medicine, Tanta University, Tanta, El-Gharbia Governorate, Egypt
Abdelaziz Abdelaal
Department of Ophthalmology, Hamad Medical Corporations, Doha, Qatar
Hashem Abu Serhan
Department of Ophthalmology, Tanta University Hospital, Tanta, Egypt
Mariam Abdelmageed Mahmoud
Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, 660003, Pereira, Risaralda, Colombia
Alfonso J. Rodriguez-Morales
Latin American network on Monkeypox Virus research (LAMOVI), Pereira, Risaralda, Colombia
Alfonso J. Rodriguez-Morales
Institución Universitaria Visión de las Américas, Pereira, Risaralda, Colombia
Alfonso J. Rodriguez-Morales
Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 4861, Peru
Alfonso J. Rodriguez-Morales
Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal
Ranjit Sah
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AA was responsible for the conceptualization of the research idea, searching the literature, making the figure, providing supervision in regards to manuscript writing, and editing and reviewing the final draft. Both RS and AJRM helped with the conceptualization of the research idea and reviewing and editing the manuscript. HAS was responsible for searching the literature, highlighting key relevant studies, making a summary table of findings, and writing the manuscript. MAM was responsible for doing literature search and writing the manuscript. All authors approved the final version of the manuscript.
Correspondence to Abdelaziz Abdelaal.
The authors declare no competing interests.
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Abdelaal, A., Serhan, H.A., Mahmoud, M.A. et al. Ophthalmic manifestations of monkeypox virus. Eye (2022). https://doi.org/10.1038/s41433-022-02195-z
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Received: 06 July 2022
Revised: 07 July 2022
Accepted: 19 July 2022
Published: 27 July 2022
DOI: https://doi.org/10.1038/s41433-022-02195-z
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